This article problematizes the position that Freud took with respect to the perspective of psychoanalysis as a natural science, as well as the later epistemological discussions. Following the distinction between sciences of the mind and sciences of nature, we evaluate what a Freudian epistemology might be. Then, we present some debates on the subject of the scientificity of psychoanalysis, and our conclusion sketches out a proposition that articulates this discussion to some of B. Latour’s ideas.